Uric Acid Level - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
Gout Attack Natural Effective Gout Treatment Treat Gouts Naturally Gout Symptoms
 

New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.


Try Goutezol for 60 Days

People Said About Goutezol Gout Treatment
"I've been suffering from gout for over 3 years. I tried many different remedies. After taking your product for 20 days I felt the difference. I'm ordering 3 more bottles to make sure I'm not going to have attack any time soon." Bill, FL
gout treatment


 HOW PEGLOTICASE WORKS

What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS

Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It has been having a decent degree of success.

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

 
Natural Remedy

People Said About Goutezol Gout Relief
"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
gout treatment


In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

SIDE EFFECTS

Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

 
 
     
 
 





Learn More about Natural Gout Remedy

One of the most common forms of arthritis is gout. Gout is characterized by joint inflammation accompanied by terrible pain and sometimes red, shiny skin covering the joint. An attack of gout appears suddenly, often overnight and most often affects the feet and ankles, with the most common area being the ball of the large toe. Gout can be cured by using natural products such as cherries,...


In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development. May was a good month for gout sufferers. Febuxostat, (EU...


If in the event of encountering throbbing pain on the part of your joints, you might immediately think of it as arthritis. Yet studies now declared a condition that has long been related to arthritis which is known as gout. On the whole, gout occurs when uric acid crystals build up in your joints, thus it is otherwise known as uric acid crystal-triggered arthritis. Symptoms of gout usually become...


Are cherries truly fruit for a healthy you? These day s people want to take care of themselves and tart cherries can help. Tart cherries naturally pack a health-promoting punch that provides pain relief for many people. Recent studies have revealed that tart (sour) cherries offer an assortment of health benefits including the ability to offer natural relief from joint pain caused from gout and...


Hundreds of Dollars! That is how much money you can save by these gout natural cures secrets. And just think you could also save yourself pain and the time to visit the doctor only to be recommended various pain killers. Gout is one of the most painful forms of arthritis! And these natural remedy gout secrets have been used for centuries. However, they seemed to be forgotten in the last...


what kind of doctor treats gout | significance of uric acid in blood | purine content chart | natural gout remedies pain | passing large kidney stone | relieving gout pain | what is a purine base | laser treatment for kidney stones | pyrimidine purine bases |







 
 
 
 
 
 
 
(c) 2019 symptomsofgout.info
Contact Us | About Us | Privacy Policy | RSS Feed | Uric Acid Level