Uric Acid Level - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
Gout Attack Natural Effective Gout Treatment Treat Gouts Naturally Gout Symptoms
 

New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.


Try Goutezol for 60 Days

People Said About Goutezol Gout Treatment
"I've been suffering from gout for over 3 years. I tried many different remedies. After taking your product for 20 days I felt the difference. I'm ordering 3 more bottles to make sure I'm not going to have attack any time soon." Bill, FL
gout treatment


 HOW PEGLOTICASE WORKS

What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS

Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It has been having a decent degree of success.

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

 
100% Natural and Safe Remedy

People Said About Goutezol Gout Treatment
"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
gout treatment


In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

SIDE EFFECTS

Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

 
 
     
 
 





Learn More about Natural Gout Remedy

Under normal circumstances, the purines you find in many foods are broken down into uric acid, and the body gets rid of it without any problems. However, for someone with gout, getting rid of this uric acid is problematic, and the result is painful crystals forming in the joints - leading to gout pain. When this happens, there are medications that can help with the pain, but one of the best...


Arthritis is the #1 cause of disability in America today, impacting approximately seven million people. It is now one of the most prevalent chronic health problems. The estimated annual costs of arthritis to Americans are $15 billion in direct medical costs and $49 billion in indirect costs such as lost wages. Nearly 40 million Americans have arthritis, with 24 million of them being under 65...


Gout treatment, like many other disease treatments, is aimed at relieving the symptoms and not at healing gout, because this is not possible. Gout treatment also tries to prevent long term damage of your joints. One you have gout there is nothing you can do to cure this medical condition, but with the proper treatment you can prevent other bad things from happening as a result of gout and you can...


Definition Uric acid tests are tests that are done to measure the levels of uric acid in blood serum or in urine. Purpose The uric acid tests are used to evaluate the blood levels of uric acid for gout and to assess uric acid levels in the urine for kidney stone formation. The urine test is used most often to monitor patients already...


Most fruits and vegetables are high in potassium. Potassium regulates electrolytes in the body and has the ability to get rid of uric acid crystals from the blood. Potassium-rich fruits are bananas, avocados, apricots and cantaloupe. High-potassium vegetables include spinach, potatoes, asparagus, beets and pumpkin. Purines are mostly found in foods which are high in protein and fat...


kidney stone infection | current research on kidney stones | home remedies for dissolving kidney stones | gout treatment diet | cranberries and gout | what is purines dna | what causes kidney stones in children | definition of kidney stones | kidney stone natural treatment | synthesis of purine nucleotides | reduce uric acid | distinguish between purine and pyrimidine bases |







 
 
 
 
 
 
 
(c) 2018 symptomsofgout.info
Contact Us | About Us | Privacy Policy | RSS Feed | Uric Acid Level