foods that lower uric acid - A New Gout Drug. Febuxostat wins marketing approval in the European Union
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A New Gout Drug. Febuxostat wins marketing approval in the European Union

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.


At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.


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  IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

As we know, prevention is better than treatment; avoiding the intake of food high in uric acid can readily prevent the occurrence of gout. Reducing alcohol consumption is also often helpful.

Scientists are now beginning to explore the effects of anthocyanins and flavonoids on uric acid production. The Medical Universities are putting out more concrete evidence continually, concerning the health benefits associated with these Tart Cherries. Gout Cherry Juice is made from these Tart Cherries, and the comments from users are showing that the benefits drawn from the juice can relieve the pain and inflammation associated with gout, pleasing many people who are afflicted with the disease. It is always recommended to check with your doctor before discontinuing medication, or making large changes in your diet. For more information about Gout Diet?, feel free to visit us at: http://www.about-goat.info/Articles/Gout_Diet.php

And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

There are many natural products available in the market. Incorporate flax seed or omega 3 oil into your diet to help reduce inflammation and tissue damage. Burdock root can help rid the body of acidic waste build up and help supports normal uric acid levels in the body.

Long known for their gorgeous bright red color, Tart Cherries are now found to be much, much more than simply a tart and delicious fruit. The relief gout sufferers have noticed upon drinking Gout Cherry Juice has been recorded, and some have even been able to come off of all their medications because of the great changes. The pain associated with gout is a constant menace to those afflicted. Medication is available, and helps, but as with any medication-- there are side effects. For those sufferers willing to change their diet, Gout Cherry Juice can reduce many side effects and do away with them completely in many circumstances.

There is no cure for gout, but it can be controlled and treated. Usually, the pain associated with gout will subside within 24 hours after treatment has begun. The main objectives of treatment are pain relieving and prevent future attacks of gout.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

Gout occurs more often in men than it does in women, but women are more susceptible after menopause. Here are some things you can do for immediate pain relief:

Any one of these remedies should work to give you some immediate relief, but in order to eliminate gout for good you will need to do some research on how to lower uric acid levels in your body. You should also support your kidneys using supplements, herbs and foods that improve kidney function.

Gout is an affliction usually associated with men over the age of 40, and is a type of arthritis that involves uric acid concentration. Uric acid is a byproduct of the liver process; you need a certain amount of it in your bloodstream. When high concentrations occur, needlelike crystals of monosodium urate form in the bloodstream settling in the joints causing inflammation and pain, which are all symptoms of gout.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

Colchicine is a traditional drug used since the 1800's as a treatment for gout. Although Colhicine produces desirable results, it does have side effects of nausea, vomiting, and diarrhea.

Gout is a very painful health problem that usually effects the big toe. It can, however, effect other joints such as the fingers, knees, etc. It is caused by the build up of crystals of uric acid depositing in the tissues of the body. When the body is unable to break down uric acid it accumulates causing inflammation of the joint(s). Uric acid is also known for causing kidney stones.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

You can make a charcoal/flaxseed poultice. You mix 1/2 cup activated powdered charcoal and 3 tablespoons finely ground flaxseed. Add warm water until you create a paste. Put the paste directly on the affected area and cover with a cloth or some plastic. Change the dressing every four hours or leave on over night. Be sure to cover the poultice carefully as charcoal can stain your bedding or clothing. You can also take activated charcoal orally to lower uric acid levels. Take 1/2 teaspoon when you first wake up, at mid-morning, at mid-afternoon and again at bedtime.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

The non-steroidal anti-inflammatory drugs (NSAID) are also used to treat gout, which does not have the side effects of colhicine. Indomethacin is a widely used NSAID in the treatment of gout. Patients should avoid Aspirin and aspirin-containing products during the attack of gout.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

 
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Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

You can use a Castor oil pack. Soak a piece of white flannel in warm Castor oil, wring out excess and place over the affected area. You then cover it with plastic wrap and apply heat using a heating pad or hot water bottle. Do this twice daily for about one hour.

Many gout sufferers have been drinking Gout Cherry Juice and have so far been reporting amazing results. It seems that drinking Gout Cherry Juice on a daily basis has kept numerous sufferers free from attacks. Also, comments from those who have not had daily intakes of the juice have claimed that when an attack starts if they begin to drink the juice, they will immediately notice a reduction in the length of the attack, as well as a great change in the severity of the attacks. These results typically convince them to begin drinking the juice every day.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

Although gout is well known, it is not a typical arthritic condition. Gout is caused by an accumulation of uric acid crystals in joints, causing joint pain and inflammation.

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Zyloprim, is a potent treatment for gout, and is usually prescribe for gout patients with kidney stones or other kidney problems. This drug slows down the rate of production of uric acid by the body. The patients who took this drug showed side effects such as skin rashes and stomach upset. Both of these symptoms usually go away as the body began accustomed to the drug.

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

Normally, uric acid dissolves in your blood and then passes through your kidneys into your urine. Sometimes your body either produces too much or excretes too little of this acid. When that happens uric acid can build up forming sharp, needle-like crystals (urate) in a joint or surrounding tissue that causes pain, inflammation and swelling. The cause of intense pain is when inflammation occurs in the joint as white blood cells surround the uric acid crystals. This causes intense pain, heat and redness

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

Gout Cherry Juice is made from Tart Cherries, which contain anthocyanins and flavonoids. These naturally occurring ingredients are what appears to be helping out the gout patients.

Use an Epsom salt foot bath. Put 2 to 3 tablespoons of Epsom salts in a pan or basin of hot water big enough to put your foot in. Soak your foot for about a 1/2 hour. You can also take a whole body bath in Epsom salts. This is especially helpful if the gout pain is in another part of the body. There are usually instructions on the Epsom salts package but you should use about one or two cups.

Alcoholic beverages should not exceed 3 ounces per day. Reduce or eliminate the purine-containing foods such as organ meats (sweet breads, liver, and kidneys), shrimp, sardines, dried legumes, and anchovies.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

Reduce pain by alternating hot and cold applications. Soak the joint in hot water for three minutes and then in cold water for a half minute. Do this about three times,

Those people who have had multiple attacks or developed tophi or kidney stones should stabilize uric acid level in the blood. Probenecid is an important drug, which helps the kidney, eliminate uric acid. Another drug called Alopurinol is used to block the excess production of uric acid by the body. The drug of choice between these types of drugs depends upon the quantity of uric acid excreted through urine.

If you suffer from gout, see your doctor and discuss a pain relief program and a correct diet to reduce gout occurrences. With correct treatment and diet, gout outbreaks can be well controlled.


 
 
     
 
 





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